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rad 140 powder for sale. The decline in testosterone levels in men during normal aging increases risks of dysfunction and disease in androgen-responsive tissues, including brain. The use of testosterone therapy has the potential to increase the risks for developing prostate cancer and or accelerating its progression. rad 140 powder for sale To overcome this limitation, novel compounds termed “selective androgen receptor modulators” (SARMs) have been developed that lack significant androgen action in prostate but exert agonist effects in select androgen-responsive tissues. The efficacy of SARMs in brain is largely unknown. SARMs.
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It’s been investigated the SARM RAD140 in cultured rat neurons and male rat brain for its ability to provide neuroprotection, an important neural action of endogenous androgens that is relevant to neural health and resilience to neurodegenerative diseases. rad 140 powder for sale In cultured hippocampal neurons, RAD140 was as effective as testosterone in reducing cell death induced by apoptotic insults. Mechanistically, RAD140 neuroprotection was dependent upon MAPK signaling, as evidenced by elevation of ERK phosphorylation and inhibition of protection by the MAPK kinase inhibitor U0126. Importantly, RAD140 was also neuroprotective in vivo using the rat kainate lesion model. SARMs. rad 140 powder for sale
Clinical utility of SARMs for neural disorders requires that they mimic androgen actions in brain. Although efficacy of SARMs for peripheral tissues such as muscle is well established, the extent to which SARMs exert protective androgen effects in brain is unclear. SARMs. rad 140 powder for sale To begin addressing this issue, we evaluated the neuroprotective efficacy of the SARM RAD140 using in vitro and in vivo paradigms previously demonstrated to be androgen responsive. RAD140 is a novel SARM with high affinity and specificity for AR, is orally available, and exhibits potent anabolic effects in rodents and nonhuman primates . buy rad-140 powder online
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We determined the effects of RAD140 against toxic insults in both primary neuron cultures and the rat kainate lesion, an animal model of hippocampal neuron loss relevant to neurodegenerative diseases , which has previously been established to respond to androgen neuroprotection . These data represent the first preclinical report investigating the neuroprotective actions of SARMs. rad 140 powder for sale
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