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Aspartate aminotransferase (AST), which is also called glutamate oxaloacetate transaminase (GOT), belongs to the group of transaminases. AST catalyzes the transfer of the amine group from -L-aspartate to negative alpha-ketoglutarate and its thydyl to -L-glutamate. AST is widely distributed in the body, but the highest levels of the enzyme are found in the heart, liver, skeletal muscles, and kidneys. AST concentration increases in case of damage to these tissues. In some forms of viral hepatitis, the enzyme increases significantly. In myocardial infarction, AST activity increases and reaches its highest level after 18-24 hours, and if the infarction does not occur again, the activity of the enzyme gradually decreases and returns to normal after 4-5 days.
Following some pathological conditions, including necrosis or any damage to liver cells, such as alcohol consumption and some drugs, the AST level is moderate and in hepatitis caused by alcohol consumption, gangrene muscular dystrophy, infectious mononucleosis, acute pancreatitis, heart diseases such as Myocarditis and pericarditis, pulmonary embolism, etc. enzyme activity increases. On the other hand, the level of AST in the serum decreases when there is a deficiency of vitamin B6.
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