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About 55% of the body's total magnesium is in the bones and the rest is inside the cells. Magnesium and potassium are two very important cations. Mg is a cofactor of many enzyme systems, including ATP-dependent enzymes. Only 1% of the total magnesium is transported in the blood. In serum, approximately 55% of magnesium is free, 30% with proteins (mainly albumin) and 15% in complexes with phosphate, citrate and other anions. Since it does not have a great ability to retain magnesium, a severe decrease in magnesium is usually not observed. Magnesium loss in the blood can be caused by its loss through the kidneys, digestive system disorders, and some treatment methods. Decrease in magnesium causes increase in neuromuscular excitability and can cause decrease in blood calcium along with neurological symptoms. An increase in magnesium in the blood almost always occurs due to an increase in consumption (parenteral therapy, improper dosage of therapeutic compounds such as magnesium sulfate), a decrease in magnesium excretion in severe renal failure, and treatment with compounds containing magnesium (gastric lavage, antacids) can cause an increase in magnesium in the blood. . Depression of the neuromuscular system is one of the main examples of magnesium poisoning.
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