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Pharmacological Classification: Antisectic
Therapeutic classification: antidepressant
Mechanism of action: By inhibiting open absorption of serotonin and norepinephrine, it has anti-depressant properties.
Pharmacokinetics: It is well absorbed from the gastrointestinal tract. Maximum plasma concentration 6 hours after ingestion with empty stomach and 10 hours with full stomach, food in stomach will reduce drug absorption.
Indications:
Depressive and resistant to other drugs
General Anxiety Therapy (GAD)
Neurodegenerative Surgeon Control (DPNP)
Fibromyalgia control (FM)
Control of chronic skeletal muscle pain (chronic low back pain - osteoarthritis)
Duloxytine is a serotonin and norepinephrine reuptake inhibitor that has been approved in Europe and the United States for the treatment of diabetic polyneuropathy.
Relevant Items Before Use:
Seizures or epilepsy
Bleeding or clotting disorders
High blood pressure
Glaucoma
Bipolar disorder (depression mania)
A history of drug abuse or suicidal thoughts
Consumption during pregnancy and lactation:
Quetiapine is part of C during pregnancy.
It is unclear whether this medicine will harm your baby, but if you are pregnant or intend to become pregnant, be sure to consult your doctor about using this medicine.
Common side effects:
Dry mouth
Drowsiness
feeling exhausted
Mild nausea or loss of appetite
Constipation
Drug Interactions:
Since the metabolism of this drug is predominantly liver, it interferes with other drugs that have liver metabolism.
Interferes with monoamine oxidant inhibitors.
Duloxetine increases the effect of these drugs: aspirin-metoclopramide, α-agonists and beta-tamoxifen-anti-depressant drugs
The effect of duloxetine decreases with these drugs: cyproterone acetate, peg interferon alpha 2b
Several studies looked at the effectiveness of duloxetine and its comparison with other drugs. A meta-analysis performed in 2009 showed that duloxetine has comparable efficacy for treating neuropathic pain with other drugs, including pregabalin and gabapentin.
A study by Wausen et al in 2009 found that duloxetine is well tolerated by most patients and is effective for the treatment of diabetic neuropathic pain irrespective of the age of the patient.
According to another study conducted in England in 2008, the use of duloxetine is effective and cost effective for the improvement of neuropathic pain.
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