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Drug Category: Thrombolytic
Features and effects:
Retals is a recombinant tissue plasminogen activating peptide that converts endogenous plasminogen into plasmin. Plasmin causes fibrin degradation in the clot, and the clot is lost.
Pharmacokinetics:
Ratllazis is excreted in the urine by the liver and kidneys after injection. The half-life of the drug is between 13 and 16 minutes.
Indications:
Acute myocardial infarction is used to reduce the risk of congestive heart failure and mortality due to lymphocytic leukemia. This drug may also be used for the treatment of pulmonary embolism and also for deep venous thrombosis.
Amount and method of administration:
The dose of reptalase is 10 units, given by intravenous injection (within two minutes). This dose is repeated one more time, half an hour after the first dose. The total dose of this drug is 20 units.
prohibited usage:
It is a drug for susceptibility to drugs and other formulations, active hemorrhage, history of cerebrovascular accident, recent history of surgery, or intracranial or intrathecal injury, intracavitary neoplasm, anomalies or vascular aneurysms, severe uncontrolled high blood pressure, and individuals Who are prone to bleeding, are contraindicated.
Caution:
Large recent surgery, cerebrovascular disease, recent gastrointestinal bleeding or urinary tract infection, high blood pressure, acute pericarditis, severe thrombophlebitis, severe renal or hepatic dysfunction, recent use of anticoagulants, hemorrhagic diabetic retinopathy, age above 75 years .
Pregnancy and breastfeeding:
This drug is in Group C during pregnancy. The lack of secretion of rupplas into milk has not been proven, so taking medication during this period should be taken with caution.
Side effects:
Fever, nausea, vomiting, bleeding, pain or redness or swelling at the injection site.
Drug Interactions:
Ratlipid concomitant use of drugs such as aspirin, dipyridamole, heparin and warfarin may increase the risk of bleeding. Therefore, precautions must be taken. Also, heparin and rtplase are incompatible in the injection and should not be injected from the common venous line. If needed, each line should be flush before injection of reptalase by 5% dextrose.
Packaging:
Each Retral® kit contains two 18-mg once-a-duplicate vials (equivalent to 10 rectal units), two single-use vials (each containing 10 ml of sterile water for injection), two 10 ml sterile syringes, four Sterling needle is.
Storage conditions:
Store at 2 to 8 ° C (in the refrigerator) and away from light.
Saler Company Information
