Warning: This medication is contraindicated during pregnancy and lactation. Due to the possibility of developing fetal abnormalities from one month before, during use and at least one month after discontinuation of the drug, use of safe contraceptive methods And stop breast-feeding for up to one month after discontinuing the drug.

The mechanism of the work:

Effects on sebaceous glands: Reduced proliferation of fat cells, reduced fat production, decreased fat glands

Effect on the Keratinization Process: Reduction of Hypercreatinization

Effects on inflammatory lesions: Inhibition of the function and proliferation of p.acnes bacteria and inhibit the production of inflammatory mediators

Dosage: Starting daily treatment for most patients at a dose of 0.5-1mg / kg. Dosage adjustment should be based on the patient's sensitivity and conditions.

It is best to take this medicine with food 1-2 times a day. Avoid chewing or sucking capsules. Typically, it lasts between 16-24 weeks. Improvement of the acne and its lesions continues for 8 weeks after discontinuation of the drug, so at least 8 weeks after taking, the new course of treatment should not be initiated.

Dose Adjustment: In patients with severe renal failure, treatment should begin with lower doses (10 mg / day), then increase the dose based on the patient's tolerance.

In highly sensitive patients, the highest tolerable dose (MTD) should be prescribed to the patient, but the likelihood of returning lesions and prolonging the course of treatment.

This medicine is not recommended for people under the age of 12 years.

Signs of overdose: Signs of acute hypoperrectomyoma A including severe headache, nausea and vomiting, drowsiness, irritability and itching.

Drug Interaction: Do not take medications such as vitamin A derivatives, tetracycline and anti-acne peeling medications.

Laboratory Monitoring Required:

Pre-treatment controls:

Performing liver tests one day before starting treatment

Conduct pregnancy tests and blood lipid tests during treatment

Perform Liver Tests: For 2 weeks once, until a response to treatment is observed

Performing the blood glucose test and enzyme cpk

Contraindications:

In pregnant and breastfeeding women

Flaw in liver function

Hypervitamin A (high levels of vitamin A in the body)

Hyperlipidemia (high blood lipids)

Sensitivity to soy and retinoid derivatives

Concomitant use with some antibiotics such as tetracyclines

Adverse effects:

Skin and mucosal tissue: Dry skin and flaking, itching, cutaneous rash, brittleness and thinning of the skin, sensitivity to light, dry mouth of the mouth and vagina.

Blood and lymphatic system: Anemia, Thrombocytopenia, Thrombocytosis and Neutropenia

Central nervous system: headache, confusion and drowsiness

Eyes: Blepharitis, Conjunctivitis, dry eye, and irritability

Respiratory system: Epistaxis, dyspnea, Rhinopharyngitis

Liver: Elevation of liver enzymes such as ALT and AST (reversible and temporary)

Connective tissue and musculoskeletal system: muscle and joint pain

Fat metabolism: triglyceride, cholesterol, and HDL reduction

Advice on use:

It is advisable to use moisturizing creams and ointments, along with a moisturizing and nutritious lip balm, during the course of treatment with curtain to relieve dry skin and lips.
Avoid taking peeling products and products during treatment, and avoid exposure to direct sunlight, even on cloudy days. Use the SPF sunscreen for days to fit your skin type. Avoid exposure to UV or solar bulbs.
During treatment and at least 6 months after discontinuation of the drug, wax, wax, skin scratching and laser treatments should be avoided.
In case of excessive dry eye, it is better to use glasses instead of lenses. Given the possibility of confusion and blurred vision, avoid driving during the course of the treatment and doing things that require full vigilance.
Blood donation should be avoided during medication and up to 1 month after it is stopped.
Initiation of treatment with coraena should be done at low dose in people with asthma or respiratory distress.
One month before and during the course of treatment, at least one and preferably two contraceptive methods should be used.